Using in silico methods to determine optimal tapering regimens for decanoate-based long-acting injectable psychosis drugs
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Authors
O’Neill JR, Taylor DM, Horowitz MA
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Issue Date
Sep-24
Type
Journal Article
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Keywords
Mental Health
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Abstract
Abstract
Background: Reducing the dose of psychosis drugs in a gradual hyperbolic manner may minimise withdrawal effects and risk of relapse. There is presently limited guidance on tapering decanoate-based long-acting injectable dopamine antagonists (LIDAs).
Objectives: We aimed to apply hyperbolic principles of tapering to the decanoate-based LIDAs flupentixol, zuclopenthixol and haloperidol to develop withdrawal regimens.
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Citation
Therapeutic Advances in Psychopharmacology. 2024;14. doi:10.1177/20451253241272790
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Journal
Therapeutic Advances in Psychopharmacology
Volume
14